Polypodium Leucotomos Extract


Polypodium Leucotomos Extract

This page intends to be a space where you can find more information about the scientific studies and research tests proving the benefits from the use of the ingredients present in SOLEIL, this page is only for educational purposes, not expecting to promote our product. SOLEIL is a dietary supplement, that is, it’s not intended to treat, prevent, cure or mitigate any disease or any symptom.
It’s important to mention that discussion, results and conclusions from each study may not be supported by all scientists or no other researcher, sometimes there are opposition to the extension from benefits of that particular ingredient.
Polypodium leucotomos extract contains a high percentage of phenolics such as caffeic acid and ferulic acid, antioxidants which protect the skin against erythema. An antioxidant is a substance that inhibits the oxidation of other molecules, it protects the body from free radicals.
Recently, in a Journal of Photochemistry and Photobiology study, this extract helped preserve human skin's fibroblasts, which build and restore collagen to help combat wrinkles and sagging skin.

The fern extract inhibits the formation of free radicals and also prevents UV rays from suppressing immune function, which is important in preventing harmful cellular changes that could lead to the development of skin cancer.

Another research in the International Journal of Dermatology suggests that the extract raise the skin resistance to UV rays, working as an adjuvant for the topical sunscreen.

In the text below you can find more information about the scientific studies that serve as background support to the benefits from Polypodium Leucotomos Extract usage.

CLINICAL RESEARCH PUBLICATIONS

The Impact of Oral Polypodium Leucotomos Extract on Ultraviolet B Response: A Human Clinical Study

ABSTRACT
There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen. This study was designed to objectively evaluate the molecular and photobiological effects of oral administration of Polypodium leucotomos extract (PLE). In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser). Evaluation was done immediately and 24 hours after irradiation. On days 3 and 4, irradiation and evaluation process was repeated after ingestion of PLE.Clinical assessments and colorimetry data showed a decrease in UVB-induced changes in 17 of 22 subjects post-PLE administration; histology findings demonstrated such a decrease in all 22 subjects.
Download
Polypodium Leucotomos Extract: A Status Report on Clinical Efficacy and Safety
ABSTRACT
Various extracts of polypodium leucotomos (PLE) applied topically or taken orally have been shown to have several beneficial antioxidant, photo protectant, antimutagenic, and immunoregulatory effects. Modern studies have evaluated the efficacy of PLE orally as a photoprotective agent and for use in several photo-aggravated dermatologic disorders such as polymorphous light eruption, other photodermatoses, and melasma. No articles have been published evaluating the safety of PLE. We performed a PUBMED search for any randomized clinical trials related to PLE, or anapsos, a synonym. The primary safety endpoint of the review was any mention of an adverse event, side effect, or toxicity. Overall, 19 human and 6 basic science studies were included spanning over 40 years of research. Oral PLE was administered at daily doses ranging from 120 mg to 1080 mg. No adverse effects were reported in laboratory studies. In humans, side effects (gastrointestinal complaints and pruritus) were mild to moderate and found only in very small numbers of patients overall (16/1016 [2%]). This review&n bsp;concludes PLE is well tolerated at all doses administered and associated with a negligible risk of side effects.
Download
Polypodium Leucotomos: A Potential New Photoprotective Agent
ABSTRACT
As the understanding of the immune system pathways, cytokine balances, and cellular interactions continues to expand, so must the potential applications of therapies that can impact the process of diseases instead of just controlling their symptoms. In the case of Polypodium leucotomos extract, which is derived from a tropical fern of the Polypodiaceae family, the future potential of applications in dermatology and beyond will be better understood as its incorporation into daily routines gives rise to the development of new regimens. Clinicians may position this agent as an option for daily maintenance, accept its use in combinations, or use it as a template for further development of oral supplementation that may evolve into a true immunomodulator.
Download
Sun Protection in a Pill: The Photoprotective Properties of Polypodium Leucotomos Extract
ABSTRACT
Physical blocks (i.e. wearing appropriate clothing), exposure avoidance, and the use of sunscreens are the main methods of photoprotection currently used. However, phytochemical and natural botanical extracts such as polypodium leucotomos, a tropical fern found in Central and South America, demonstrate a strong potential as adjuncts to sunscreen protection. A review of the literature was performed focusing on the photoprotective properties of PL extracts, including antioxidant, immunoregulatory, anti-inflammatory and antitumorigenic effects in the context of sunburn, photodermatoses, chronic skin damage, photoaging, and skin cancer. PL supplementation acts at a molecular and cellular level to enhance endogenous antioxidant systems and inhibit generation of reactive oxygen species, thus decreasing UV-mediated oxidative DNA mutations. PL has also been shown to accelerate removal of UV-induced photoproducts, highlighting its anti-carcinogenic role. By reducing UV-induced inflammatory responses and inhibiting extracellular matrix remodeling, PL demonstrates some protective effects against photoaging and PUVA induced phototoxicity. The use of a systemic protective agent would provide significant advantages such as a more uniform coverage over the total body surface area, regardless of individual factors such as potency of the creams, amount applied, sweating, or bathing. Oral administration of PL extracts and its favorable safety profile could have significant implications in the prevention of skin cancer.
Download
Role of Oral Polypodium Leucotomos Extract in Dermatologic Diseases: A Review of the Literature
ABSTRACT
Polypodium leucotomos extract (PLE), derived from the tropical fern of Polypodiaceae family, has properties ranging from immunomodulatory and antioxidative to photoprotective. It is these multiple mechanisms of action, in combination with a favorable side effect profile, which makes PLE a promising adjunctive treatment for several dermatologic disorders. Studies are summarized on the use and potential applications of PLE in the treatment or management of photodermatoses, vitiligo, melasma, psoriasis, atopic dermatitis, and more recently, in minimizing infections in high-performance athletes. More data, however, with larger sample sizes are needed to confirm these benefits.
Download